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用23andMe公司的89,283客户的基因型数据做GWAS

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发表于 2017-3-2 09:10:33 | 显示全部楼层 |阅读模式
用23andMe公司的89,283客户的基因型数据做GWAS,看看哪些位点跟生物钟有关,早睡早起,晚睡晚起什么的。有兴趣的看看,写一个简单的介绍:http://www.nature.com/articles/ncomms10448

需要排除age, gender, BMI, alcohol abuse, nicotine abuse and current caffeine use这些信息对gwas位点的关联性的干扰


For known circadian genes such as DEC1, DEC2, BMAL1, CRY1 and CRY2, we did not find signals that were genome-wide significant. Specifically, within 100 kb windows of each gene, we had 1,712 SNPs for DEC1 with a minimum P value 0.01;

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