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癌症和肥胖的关系?

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发表于 2017-3-3 15:42:06 | 显示全部楼层 |阅读模式
这篇文章谈了好几点,推荐大家阅读:http://cjcjournal.biomedcentral. ... 6/s40880-017-0185-8

Question 1

Cancer and obesity are heterogeneous. Which molecular subtypes of cancer are related to or caused by “malignant” obesity?

Question 2

Through which factors/genes/signaling pathways does adipose tissue influence tumorigenesis?

Question 3

Are there common (overlapping) genetic loci that make individuals susceptible to obesity, metabolic syndrome, and cancers?

Question 4

Are there precursor lesions of ORCs, and will their identification help alter the natural history of such cancers?

Future studies are expected to explore the following directions:
A clearer definition of pathological obesity that can be measured easily.
Molecular profile of ORCs based on such criteria.
Expanded research into the causative mechanism(s).
Research into uncoupling obesity from cancer and MetS by targeting the responsible genes.
Repurposing of drugs currently used in MetS to test their efficacy in the prevention and treatment of ORCs.



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你这个问题很复杂,需要打赏,请点击 http://www.bio-info-trainee.com/donate 进行打赏,谢谢
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