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70个Chromosomal instability (CIN)相关基因的表达作为癌症预后marker

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发表于 2017-3-5 00:25:01 | 显示全部楼层 |阅读模式
读的这篇文章是:Chromosomal instability as a prognostic marker in cervical cancer
最近比较感兴趣染色体不稳定的问题:http://bmccancer.biomedcentral.c ... 6/s12885-015-1372-0

文章说前面有文献提到了:
Over-expression of this CIN70 signature was predictive of poor clinical outcome in 12 datasets representing six types of tumour: lymphoma, lung adenocarcinoma, glioma, medulloblastoma, mesothelioma, and breast cancer
所以作者就分析了70个Chromosomal instability (CIN)相关基因的表达情况,在 cervical cancer里面!

但是作者同时其实还下载了拷贝数变异数据,还有点突变数据。
Level 3 copy-number (SNP 6.0 arrays; Affymetrix), gene-expression (RNA-Seq; Illumina) and somatic mutation (Exome-Seq; Illumina) data were downloaded from the Broad GDAC Firehose (http://gdac.broadinstitute.org/), and analyzed in the R statistical environment.

这篇文章没有太大的价值,纯粹是灌水,分析的就是previously published CIN70 signature

你这个问题很复杂,需要打赏,请点击 http://www.bio-info-trainee.com/donate 进行打赏,谢谢
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