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snp2tfbs是一个研究人类基因组调控原件变异引起相关分子调...

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发表于 2017-3-16 09:31:45 | 显示全部楼层 |阅读模式
SNP2TFBS – a database of regulatory SNPs affecting predicted transcription factor binding site affinity
数据库网址:http://ccg.vital-it.ch/snp2tfbs/
snp2tfbs是一个研究人类基因组调控原件变异引起相关分子调控机制改变的数据库。

具体英文摘要:

SNP2TFBS is a computational resource intended to support researchers investigating the molecular mechanisms underlying regulatory variation in the human genome. The database essentially consists of a collection of text files providing specific annotations for human single nucleotide polymorphisms (SNPs), namely whether they are predicted to abolish, create or change the affinity of one or several transcription factor (TF) binding sites. A SNP's effect on TF binding is estimated based on a position weight matrix (PWM) model for the binding specificity of the corresponding factor. These data files are regenerated at regular intervals by an automatic procedure that takes as input a reference genome, a comprehensive SNP catalogue and a collection of PWMs. SNP2TFBS is also accessible over a web interface, enabling users to view the information provided for an individual SNP, to extract SNPs based on various search criteria, to annotate uploaded sets of SNPs or to display statistics about the frequencies of binding sites affected by selected SNPs.
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