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TcoF-DB v2 是一个收录人和小鼠的调控转录因子的 co-factors 数...

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发表于 2017-3-16 10:01:11 | 显示全部楼层 |阅读模式
TcoF-DB v2: update of the database of human and mouse transcription co-factors and transcription factor interactions
TcoF-DB v2 是一个收录人和小鼠的调控转录因子的 co-factors 数据库。
具体英文摘要:
For the regulation of transcription, interactions of different regulatory proteins known as transcription co-factors (TcoFs) and TFs are essential in forming necessary protein complexes. Although TcoFs themselves do not bind DNA directly, their influence on transcriptional regulation and initiation, although indirect, has been shown to be significant, with the functionality of TFs strongly influenced by the presence of TcoFs. In the TcoF-DB v2 database, we collect information on TcoFs. In this article, we describe updates and improvements implemented in TcoF-DB v2. TcoF-DB v2 provides several new features that enables exploration of the roles of TcoFs. The content of the database has significantly expanded, and is enriched with information from Gene Ontology, biological pathways, diseases and molecular signatures. TcoF-DB v2 now includes many more TFs; has substantially increased the number of human TcoFs to 958, and now includes information on mouse (418 new TcoFs). TcoF-DB v2 enables the exploration of information on TcoFs and allows investigations into their influence on transcriptional regulation in humans and mice.
网址:http://tcofdb.org/.
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