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正常人体内细菌等微生物的个数是细胞的个数的10倍?1倍?

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发表于 2017-5-2 14:57:19 | 显示全部楼层 |阅读模式
早在1972年,微生物学家 Thomas Luckey 就估算人体内细菌等微生物的个数是细胞的个数的10倍。
2014年,分子生物学家 Judah Rosner 对这个数值提出过怀疑,但直到2016年,用mass才重新理论估算了比例应该是接近1:1


It's often said that the bacteria and other microbes in our body outnumber our own cells by about ten to one. That's a myth that should be forgotten, say researchers in Israel and Canada. The ratio between resident microbes and human cells is more likely to be one-to-one, they calculate.


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A 'reference man' (one who is 70 kilograms, 20–30 years old and 1.7 metres tall) contains on average about 30 trillion human cells and 39 trillion bacteria, say Ron Milo and Ron Sender at the Weizmann Institute of Science in Rehovot, Israel, and Shai Fuchs at the Hospital for Sick Children in Toronto, Canada.

Those numbers are approximate — another person might have half as many or twice as many bacteria, for example — but far from the 10:1 ratio commonly assumed.

“The numbers are similar enough that each defecation event may flip the ratio to favour human cells over bacteria,” they delicately conclude in a manuscript posted to the preprint server bioRxiv1.


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The 10:1 myth persisted from a 1972 estimate by microbiologist Thomas Luckey, which was “elegantly performed, yet was probably never meant to be widely quoted decades later”, say the paper’s authors. In 2014, molecular biologist Judah Rosner at the US National Institutes of Health at Bethesda, expressed his doubts about the 10:1 claim, noting that there were very few good estimates for the numbers of human and microbial cells in the body.

Milo, Sender and Fuchs decided to re-estimate the number by reviewing a wide range of recent experimental data in the literature, including DNA analyses to calculate cell number and magnetic-resonance imaging to calculate organ volume. The vast majority of human cells are red blood cells, they note (see 'Counting human cells').


A particular overestimate in Luckey’s work relates to the proportion of bacteria in our guts, Milo and colleagues say. Luckey estimated that guts contain around 1014 bacteria, by assuming that there were 1011 bacteria in a gram of faeces, and scaling that up by the one-litre volume of the alimentary canal, which stretches from the mouth to the anus.


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But most bacteria reside only in the colon (which has a volume of 0.4 litres), Milo and colleagues point out — and measurements suggest that there are fewer bacteria in stool samples than Luckey thought.

Putting together these kinds of calculations, the researchers produce a ratio for microbial to human cells for the average man of 1.3:1, with a wide uncertainty. Milo declined to comment on the paper, because it is in review at a scientific journal.

“It is good that we all now have a better estimate to quote,” says Peer Bork, a bioinformatician at the European Molecular Biology Laboratory in Heidelberg, Germany, who works on the human and other complex microbiomes. “But I don’t think it will actually have any biological significance.”

Nature doi:10.1038/nature.2016.19136




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