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彻底搞不清楚脑胶质瘤到底该怎么分类了。

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发表于 2017-6-5 21:07:09 | 显示全部楼层 |阅读模式
GBM?DIPBG?
看到一篇文章:The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma
提到了
Pediatric high-grade glioma (HGG) is a devastating disease with a less than 20% survival rate 2 years after diagnosis1.

We analyzed 127 pediatric HGGs, including diffuse intrinsic pontine gliomas (DIPGs) and non-brainstem HGGs (NBS-HGGs), by whole-genome, whole-exome and/or transcriptome sequencing.

样本量是:
we analyzed the genomic landscape of HGGs from 118 pediatric cases (127 tumors, 108 matched to germline DNA) consisting of 57 DIPGs and 70 NBS HGGs by whole-genome (n = 42), whole-exome (n = 80) and transcriptome (n = 75) sequencing

测序结果是:
A total of 39,590 sequence mutations, including single-nucleotide variations (SNVs) and small insertions or deletions (indels), and 2,039 structural variations were found by whole-genome sequencing,
and an additional 2,600 sequence mutations and 138 structural variations were found by exome sequencing and transcriptome sequencing, respectively

landscape如下:





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