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肿瘤细胞反而难以重编程为iPSC

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发表于 2017-10-26 11:46:27 | 显示全部楼层 |阅读模式
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ew iPSC lines are now routinely generated from primary tissues obtained from healthy donors and various patients, as well as from different species, cell types, and developmental stages. Moreover, knockdown of tumor suppressor genes is known to enhance reprogramming efficiency.9–11 However, reprogramming human primary cancer cells has proven to be, paradoxically, inefficient. Despite significant interest in generating iPSCs from cancer cells to help elucidate the molecular mechanisms of cancer progression, there have been relatively few reports demonstrating successful reprogramming of malignant human cells. The difficulties in reprogramming cancer cells are thought to stem in part from biological barriers, including cancer-specific genetic mutations, epigenetic modifications, accumulation of DNA damage, and reprogramming-triggered cellular senescence.12–14

In spite of these difficulties, several published studies have reported the generation of novel iPSC lines from existing cancer cell lines. Reports of iPSC lines derived from human cancer cell lines are summarized in Table 1 and cover a range of cancers such as melanoma,15,16 prostate cancer,15 gastrointestinal cancers,17 chronic myeloid leukemia,18 lung cancer,19 breast cancer,20 glioblastoma,21 and sarcomas.22



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 楼主| 发表于 2017-10-26 11:46:35 | 显示全部楼层
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