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[mRNA-seq] 求助ssGSEA

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发表于 2018-4-3 23:24:05 | 显示全部楼层 |阅读模式
求助有小伙伴们知道ssGSEA吗?就是single sample GSEA
原始参考文献是:09年nuture上发表的文章Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
里面简述了ssGSEA的过程
This was accomplished by a ‘single sample’ extension of GSEA that allows one to
define an enrichment score that represents the degree of absolute enrichment of a
gene set in each sample within a given data set. The gene expression values for a
given sample were rank-normalized, and an enrichment score was produced
using the Empirical Cumulative Distribution Functions (ECDF) of the genes
in the signature and the remaining genes. This procedure is similar to GSEA but
the list is ranked by absolute expression (in one sample). The enrichment score is
obtained by an integration of the difference between the ECDF.



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