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比较一种疾病状态需要跟42种正常组织进行比较?

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发表于 2016-11-21 16:41:04 | 显示全部楼层 |阅读模式
看到一个芯片表达数据,是 gene expression profile of 23 clinical SCLC samples,检索ID是GSE43346
作者分析数据发现PRC2 相关基因在 SCLC里面比其它42种normal tissue都高表达。
粗看以为是42个肺部正常组织,normal small airway epithelial cells ,结果是42个不同的组织。
结论很重要,就是PRC2相关基因生存分析很有意义:
In clinical SCLC cases, lower JUB level correlated to shorter survival (P=0.002), or a set of PRC target genes (JUB, EPHB4) and marker genes of classic type SCLC (GRP, ASCL1) correlated to shorter survival (P=0.0001) and classified SCLC into two groups with distinct prognosis. Growth of SCLC cell lines was repressed when treated with 3-Deazaneplanocin A, an inhibitor against PRC2. It is suggested that high expression of PRC2 in SCLC contributed to repression of genes including non-PRC-target genes in ES cells, and that the gene repression may play a role in genesis of SCLC.

GSM1060726        Whole_Brain
GSM1060727        Cerebral_cortex
GSM1060728        Pons
GSM1060729        Hippocampus
GSM1060730        Diencephalon
GSM1060731        Thalamus
GSM1060732        Cerebellum
GSM1060733        Skeletal_muscle
GSM1060734        Heart
GSM1060735        Skin
GSM1060736        Tongue
GSM1060737        Esophagus
GSM1060738        Stomach
GSM1060739        Small_intestine
GSM1060740        Colon
GSM1060741        Pancreas
GSM1060742        Liver
GSM1060743        Gallbladder
GSM1060744        Kidney
GSM1060745        Adrenal_gland
GSM1060746        Bladder
GSM1060747        Salivary_gland
GSM1060748        Tonsil
GSM1060749        Thyroid
GSM1060750        Thymus
GSM1060751        Trachea
GSM1060752        Lung
GSM1060753        Spleen
GSM1060754        Adipose
GSM1060755        Lymph_node
GSM1060756        Artery
GSM1060757        Vein
GSM1060758        Bone_marrow
GSM1060759        Peripheral_blood_cells
GSM1060760        Monocyte
GSM1060761        Macrophage
GSM1060762        Testis
GSM1060763        Prostate
GSM1060764        Seminal_vesicle
GSM1060765        Breast
GSM1060766        Uterus
GSM1060767        Ovary
GSM1060768        SCLC205
GSM1060769        SCLC207
GSM1060770        SCLC209
GSM1060771        SCLC211
GSM1060772        SCLC213
GSM1060773        SCLC215
GSM1060774        SCLC219
GSM1060775        SCLC227
GSM1060776        SCLC229
GSM1060777        SCLC231
GSM1060778        SCLC233
GSM1060779        SCLC235
GSM1060780        SCLC237
GSM1060781        SCLC239
GSM1060782        SCLC241
GSM1060783        SCLC243
GSM1060784        SCLC245
GSM1060785        SCLC247
GSM1060786        SCLC249
GSM1060787        SCLC251
GSM1060788        SCLC253
GSM1060789        SCLC255
GSM1060790        SCLC257
GSM1060791        H209
GSM1060792        DMS53
GSM1060793        SAEC
GSM1060794        Lu130a
GSM1060795        Lu130b

里面还用到了3种芯片平台,感觉很无语:
GPL96        [HG-U133A] Affymetrix Human Genome U133A Array
GPL97        [HG-U133B] Affymetrix Human Genome U133B Array
GPL570        [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array



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