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癌症变异位点的临床解释数据库大全!

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发表于 2017-2-15 10:23:23 | 显示全部楼层 |阅读模式
看到我的偶像在nature genetics上面发了一个工具CIViC(http://www.nature.com/ng/journal/v49/n2/full/ng.3774.html) 用来做癌症里面的变异位点的注释,他收集了主流的其它类似的数据,分享给大家:
Cancer Genome Interpreter (CGI)         
CanDL (CDL)        
Gene Drug Knowledge Database (GDKD)        
OncoKb (OKB)        
Precision Medicine Knowledgebase (PMKB)        
Jackson Knowledgebase (JKB)        
My Cancer Genome (MCG)

负责的单位分别是:

Resource name (listed in alphabetical order)Primary institute
BaseSpace Knowledge NetworkIllumina Inc.
Cancer Driver Log (CanDL)Ohio State University (OSU)/James Cancer Hospital
Cancer Genome InterpreterUniversitat Pompeu Fabra, Barcelona, Spain
Clinical Interpretation of Variants in Cancer (CIViC)Washington University School of Medicine (WashU)
ClinVarNational Center for Biotechnology Information (NCBI)
COSMIC Drug Resistance CurationWellcome Trust Sanger Institute
Database of Curated Mutations (DoCM)Washington University School of Medicine (WashU)
Gene Drug Knowledge DatabaseSynapse
JAX Clinical KnowledgebaseThe Jackson Laboratory
My Cancer GenomeVanderbilt University
OncoKBMemorial Sloan Kettering Cancer Center
Personalized Cancer Therapy DatabaseMD Anderson Cancer Center‎
Pharmacogenomics Knowledgebase (PharmGKB)Stanford University
Precision Medicine Knowledgebase (PMKB)Weill Cornell Medical College

网址是:
Resource name (listed in alphabetical order)Citation (PubMed ID)Site URL
BaseSpace Knowledge NetworkN/Ahttp://www.illumina.com/informatics/research/biological-data-interpretation/variant-interpreter.html
Cancer Driver Log (CanDL)26320871https://candl.osu.edu/
Cancer Genome InterpreterN/Ahttps://www.cancergenomeinterpreter.org/home
Clinical Interpretation of Variants in Cancer (CIViC)10.1101/072892www.civicdb.org
ClinVar26582918http://www.ncbi.nlm.nih.gov/clinvar/
COSMIC Drug Resistance Curation25355519http://cancer.sanger.ac.uk/cosmic/drug_resistance
Database of Curated Mutations (DoCM)27684579www.docm.info
Gene Drug Knowledge Database25656898https://www.synapse.org/#!Synapse:syn2370773/wiki/62707
JAX Clinical Knowledgebase26772741https://ckb.jax.org/
My Cancer Genome23344264https://www.mycancergenome.org/
OncoKBN/Ahttp://oncokb.org/#/
Personalized Cancer Therapy DatabaseN/Ahttps://pct.mdanderson.org/#/home
Pharmacogenomics Knowledgebase (PharmGKB)22992668https://www.pharmgkb.org/
Precision Medicine Knowledgebase (PMKB)27789569https://pmkb.weill.cornell.edu/




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发表于 2017-2-22 10:04:18 | 显示全部楼层
CIViC数据库是开源的,任何人都可以免费使用,就是目前里面的数据还不多,社区还不够活跃
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