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Oncogenes的Mutant Allele Frequencies分布情况

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发表于 2017-2-17 09:59:54 | 显示全部楼层 |阅读模式
我看到一篇文章讲到:http://biorxiv.org/content/early/2016/04/07/047563
Why Mutant Allele Frequencies in Oncogenes Peak Around 0.40 and Rapidly Decrease?
就是观察到了TCGA的mutation数据文件里面的现象,然后解释。

但,事实上,Mutant Allele Frequencies这个概念本身就不清不楚的!希望有人可以介绍一下:

Allele frequency (gene frequency) is the proportion of all alleles at a locus that are of a specified type.

Polymorphism is the proportion of all genetic loci that exist in more than one allelic form. Humans,
P=0.32, D. melanogaster, H=0.42.

Heterozygosity is the proportion of individuals that are heterozygous (as opposed to homozygous) for
alternate alleles at a specific locus. Humans: H=0.06, D. melanogaster, H=0.14




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